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Template
:
PBB/6622
言語
ウォッチリストに追加
編集
<
Template:PBB
シヌクレイン, アルファ (アミロイド前駆体の非A4成分)
Synuclein, alpha (non A4 component of amyloid precursor)
PDB
1xq8
[1]
からの画像
PDBに登録されている構造
PDB
Ortholog search:
PDBe
,
RCSB
,
PDBj
PDBのIDコード一覧
1XQ8
,
2JN5
,
2KKW
,
2X6M
,
3Q25
,
3Q26
,
3Q27
,
3Q28
,
3Q29
識別記号
記号
SNCA
; NACP; PARK1; PARK4; PD1
その他ID
OMIM
:
163890
MGI
(
英語版
)
:
1277151
HomoloGene
(
英語版
)
:
293
ChEMBL
:
6152
GeneCards
:
SNCA Gene
遺伝子オントロジー
分子機能
•
magnesium ion binding
•
fatty acid binding
•
copper ion binding
•
calcium ion binding
•
protein binding
•
ferrous iron binding
•
zinc ion binding
•
oxidoreductase activity
•
kinesin binding
•
Hsp70 protein binding
•
histone binding
•
identical protein binding
•
alpha-tubulin binding
•
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
•
dynein binding
•
tau protein binding
•
phosphoprotein binding
•
phospholipase D inhibitor activity
細胞の構成要素
•
extracellular region
•
nucleus
•
cytoplasm
•
mitochondrion
•
cytosol
•
plasma membrane
•
cell cortex
•
actin cytoskeleton
•
inclusion body
•
cell junction
•
axon
•
growth cone
•
platelet alpha granule membrane
•
fibril
•
synapse
•
perinuclear region of cytoplasm
生物学的プロセス
•
microglial cell activation
•
positive regulation of receptor recycling
•
positive regulation of neurotransmitter secretion
•
fatty acid metabolic process
•
neutral lipid metabolic process
•
phospholipid metabolic process
•
activation of cysteine-type endopeptidase activity involved in apoptotic process
•
mitochondrial membrane organization
•
adult locomotory behavior
•
response to iron(II) ion
•
regulation of phospholipase activity
•
negative regulation of platelet-derived growth factor receptor signaling pathway
•
regulation of glutamate secretion
•
regulation of dopamine secretion
•
negative regulation of microtubule polymerization
•
receptor internalization
•
protein destabilization
•
response to magnesium ion
•
negative regulation of transporter activity
•
response to lipopolysaccharide
•
negative regulation of monooxygenase activity
•
positive regulation of peptidyl-serine phosphorylation
•
response to interferon-gamma
•
cellular response to oxidative stress
•
negative regulation of histone acetylation
•
regulation of locomotion
•
dopamine biosynthetic process
•
response to drug
•
mitochondrial ATP synthesis coupled electron transport
•
regulation of macrophage activation
•
negative regulation of apoptotic process
•
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
•
extracellular fibril organization
•
negative regulation of neuron apoptotic process
•
positive regulation of endocytosis
•
negative regulation of exocytosis
•
regulation of long-term neuronal synaptic plasticity
•
synaptic vesicle endocytosis
•
synapse organization
•
regulation of acyl-CoA biosynthetic process
•
positive regulation of release of sequestered calcium ion into cytosol
•
dopamine uptake involved in synaptic transmission
•
negative regulation of dopamine uptake involved in synaptic transmission
•
negative regulation of serotonin uptake
•
negative regulation of norepinephrine uptake
•
calcium ion homeostasis
•
oxidation-reduction process
•
regulation of excitatory postsynaptic membrane potential
•
long-term synaptic potentiation
•
positive regulation of inositol phosphate biosynthetic process
•
negative regulation of thrombin receptor signaling pathway
•
response to interleukin-1
•
cellular response to copper ion
•
cellular response to epinephrine stimulus
•
positive regulation of protein serine/threonine kinase activity
出典:
Amigo
/
EGO
RNA発現パターン
その他参照発現データ
オルソログ
種
ヒト
マウス
Entrez
(
英語版
)
6622
20617
Ensembl
(
英語版
)
ENSG00000145335
ENSMUSG00000025889
UniProt
(
英語版
)
P37840
O55042
RefSeq (mRNA)
NM_000345.3
NM_001042451.1
RefSeq (protein)
NP_000336.1
NP_001035916.1
Location (UCSC)
Chr 4:
90.65 - 90.76 Mb
Chr 6:
60.73 - 60.83 Mb
PubMed
search
[1]
[2]
KEGG
GENES
hsa:6622
mmu:20617
表
話
編
歴
^
Ulmer TS, Bax A, Cole NB, Nussbaum RL (Mar 2005). “Structure and dynamics of micelle-bound human alpha-synuclein”.
J Biol Chem
280
(10): 9595-9603.
doi
:
10.1074/jbc.M411805200
.
PMID
15615727
.