Template:PBB/1026

Cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Constructed from 1AXC​
PDBに登録されている構造 PDB Ortholog search: PDBe, RCSB, PDBj PDBのIDコード一覧 1AXC​, 2ZVV​, 2ZVW​
識別記号
記号	CDKN1A; CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1
その他ID	OMIM: 116899 MGI: 104556 HomoloGene: 333 ChEMBL: 5021 GeneCards: CDKN1A Gene
遺伝子オントロジー 分子機能 • cyclin-dependent protein kinase inhibitor activity • protein binding • cyclin-dependent protein kinase activating kinase activity • cyclin binding • metal ion binding 細胞の構成要素 • cyclin-dependent protein kinase holoenzyme complex • nucleus • nucleoplasm • cytosol • PCNA-p21 complex 生物学的プロセス • cell cycle checkpoint • regulation of cyclin-dependent protein kinase activity • G1 phase of mitotic cell cycle • G1/S transition of mitotic cell cycle • S phase of mitotic cell cycle • G2/M transition of mitotic cell cycle • mitotic cell cycle • response to DNA damage stimulus • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • cell cycle arrest • Ras protein signal transduction • negative regulation of cell proliferation • response to UV • response to toxin • response to organic nitrogen • negative regulation of gene expression • negative regulation of cell growth • positive regulation of B cell proliferation • organ regeneration • cellular response to extracellular stimulus • regulation of protein import into nucleus, translocation • negative regulation of phosphorylation • response to drug • negative regulation of apoptotic process • positive regulation of programmed cell death • negative regulation of cyclin-dependent protein kinase activity • response to arsenic-containing substance • positive regulation of fibroblast proliferation • response to corticosterone stimulus • response to hyperoxia • cellular response to ionizing radiation • mitotic cell cycle arrest • cellular senescence • replicative senescence • stress-induced premature senescence • intrinsic apoptotic signaling pathway • regulation of DNA biosynthetic process • positive regulation of reactive oxygen species metabolic process 出典: Amigo / EGO
RNA発現パターン
その他参照発現データ
オルソログ
種	ヒト	マウス
Entrez	1026	12575
Ensembl	ENSG00000124762	ENSMUSG00000023067
UniProt	P38936	P39689
RefSeq (mRNA)	NM_000389.4	NM_001111099.1
RefSeq (protein)	NP_000380.1	NP_001104569.1
Location (UCSC)	Chr 6: 36.64 - 36.66 Mb	Chr 17: 29.09 - 29.1 Mb
PubMed search	[1]	[2]
KEGG GENES	hsa:1026	mmu:12575