S-(ヒドロキシメチル)グルタチオンデヒドロゲナーゼ
S-(ヒドロキシメチル)グルタチオンデヒドロゲナーゼ（S-(hydroxymethyl)glutathione dehydrogenase）は、次の化学反応を触媒する酸化還元酵素である。
| S-(ヒドロキシメチル)グルタチオンデヒドロゲナーゼ | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 識別子 | |||||||||
| EC番号 | 1.1.1.284 | ||||||||
| データベース | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB構造 | RCSB PDB PDBj PDBe PDBsum | ||||||||
| 遺伝子オントロジー | AmiGO / QuickGO | ||||||||
| |||||||||
- S-(ヒドロキシメチル)グルタチオン + NAD(P)+ S-ホルミルグルタチオン + NAD(P)H + H+
すなわち、この酵素の基質はS-(ヒドロキシメチル)グルタチオンとNAD(P)+、生成物はS-ホルミルグルタチオンとNAD(P)HとH+である。
組織名はS-(hydroxymethyl)glutathione:NAD+ oxidoreductaseで、別名には以下のものがある。
- NAD-linked formaldehyde dehydrogenase (incorrect)
- formaldehyde dehydrogenase (incorrect)
- formic dehydrogenase (incorrect)
- class III alcohol dehydrogenase
- ADH3
- χ-ADH
- FDH (incorrect)
- formaldehyde dehydrogenase (glutathione) (incorrect)
- GS-FDH (incorrect)
- glutathione-dependent formaldehyde dehydrogenase (incorrect)
- NAD-dependent formaldehyde dehydrogenase
- GD-FALDH
- NAD- and glutathione-dependent formaldehyde dehydrogenase
参考文献
編集- Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
- Rose ZB and Racker E (1966). “Formaldehyde dehydrogenase”. Methods Enzymol. 9: 357–360. doi:10.1016/0076-6879(66)09073-6.
- Liu L, Hausladen A, Zeng M, Que L, Heitman J, Stamler JS (2001). “A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans”. Nature. 410: 490–4. doi:10.1038/35068596. PMID 11260719.
- Sanghani PC, Stone CL, Ray BD, Pindel EV, Hurley TD, Bosron WF (2000). “Kinetic mechanism of human glutathione-dependent formaldehyde dehydrogenase”. Biochemistry. 39: 10720–9. doi:10.1021/bi9929711. PMID 10978156.
- Probst C, Grotz M, Krettek C, Pape HC (2005). “Impact of hypothermia on the immunologic response after trauma and elective surgery”. Surg. Technol. Int. 14: 41–50. PMID 16525953.
- Stouthamer AH, Harms N (1995). “Isolation, sequencing, and mutagenesis of the gene encoding NAD- and glutathione-dependent formaldehyde dehydrogenase (GD-FALDH) from Paracoccus denitrificans, in which GD-FALDH is essential for methylotrophic growth”. J. Bacteriol. 177: 247–51. PMID 7798140.
- Barber RD, Rott MA, Donohue TJ (1996). “Characterization of a glutathione-dependent formaldehyde dehydrogenase from Rhodobacter sphaeroides”. J. Bacteriol. 178: 1386–93. PMID 8631716.