核内受容体コアクチベーター4

NCOA4
PDBに登録されている構造
PDB	Human UniProt検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1T5Z
識別子
記号	NCOA4, ARA70, ELE1, PTC3, RFG, nuclear receptor coactivator 4
外部ID	OMIM: 601984 MGI: 1350932 HomoloGene: 38052 GeneCards: NCOA4
遺伝子の位置 (ヒト)
染色体	10番染色体 (ヒト)
終点	46,030,623 bp
遺伝子の位置 (マウス)
染色体	14番染色体 (マウス)
終点	31,901,812 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• androgen receptor binding; • transcription coactivator activity;
細胞の構成要素	• 細胞核; • autolysosome;
生物学的プロセス	• androgen receptor signaling pathway; • positive regulation of transcription, DNA-templated; • 男性生殖腺発生; • transcription, DNA-templated; • regulation of transcription, DNA-templated; • protein targeting to lysosome; • cellular iron ion homeostasis; • ホルモンへの反応;
	出典:Amigo / QuickGO
オルソログ
	8031
	27057
	ENSG00000266412
	ENSMUSG00000056234
	Q13772
	n/a
	NM_005437; NM_001145260; NM_001145261; NM_001145262; NM_001145263
	NM_001033988; NM_001284319; NM_019744
	NP_001138732; NP_001138733; NP_001138734; NP_001138735; NP_005428
	n/a
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

核内受容体コアクチベーター4（NCOA4: nuclear receptor coactivator 4）は、ヒトのNCOA4遺伝子によってコードされるタンパク質である^[5]^[6]^[7]。フェリチノファジーにおいて重要な役割を果たし、カーゴ受容体として作用し、フェリチン重鎖に結合し、オートファゴソームの表面のATG8に係留される。

相互作用分子

NCOA4は以下の生体分子と相互作用する。

アンドロゲン受容体^[8]^[9]^[10]^[11]^[12]^[13]^[14]^[15]
ペルオキシソーム増殖因子活性化受容体ガンマ^[16]
フェリチン^[17]^[18]
ATG8（オートファジー関連タンパク質8）^[19]

脚注

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000266412 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056234 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ M Santoro, N A Dathan, M T Berlingieri, I Bongarzone, C Paulin, M Grieco, M A Pierotti, G Vecchio, A Fusco (February 1994). “Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma”. Oncogene 9 (2): 509–16. PMID 8290261.
^ Shuyuan Yeh, and Chawnshang Chang (28 May 1996). “Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells”. Proceedings of the National Academy of Sciences of the United States of America 93 (11): 5517–21. Bibcode: 1996PNAS...93.5517Y. doi:10.1073/pnas.93.11.5517. PMC 39278. PMID 8643607.
^ “Entrez Gene: NCOA4 Nuclear receptor coactivator 4”. アメリカ国立生物工学情報センター. 2021年8月16日閲覧。
^ Philippe Alen, Frank Claessens, Erik Schoenmakers, Johannes V. Swinnen, Guido Verhoeven, Wilfried Rombauts, Ben Peeters (1 January 1999). “Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform”. Molecular Endocrinology 13 (1): 117–28. doi:10.1210/mend.13.1.0214. PMID 9892017.
^ Hiroshi Miyamoto, Shuyuan Yeh, George Wilding, and Chawnshang Chang (23 June 1998). “Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells”. Proceedings of the National Academy of Sciences of the United States of America 95 (13): 7379–84. Bibcode: 1998PNAS...95.7379M. doi:10.1073/pnas.95.13.7379. PMC 22623. PMID 9636157.
^ Hui-Kuan Lin, Shuyuan Yeh, Hong-Yo Kang, and Chawnshang Chang (19 June 2001). “Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor”. Proceedings of the National Academy of Sciences of the United States of America 98 (13): 7200–5. Bibcode: 2001PNAS...98.7200L. doi:10.1073/pnas.121173298. PMC 34646. PMID 11404460.
^ Shuyuan Yeh, Hui-Kuan Lin, Hong-Yo Kang, Tin Htwe Thin, Ming-Fong Lin, and Chawnshang Chang (11 May 1999). “From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells”. Proceedings of the National Academy of Sciences of the United States of America 96 (10): 5458–63. Bibcode: 1999PNAS...96.5458Y. doi:10.1073/pnas.96.10.5458. PMC 21881. PMID 10318905.
^ Zhong-xun Zhou, Bin He, Susan H. Hall, Elizabeth M. Wilson, Frank S. French (1 February 2002). “Domain interactions between coregulator ARA(70) and the androgen receptor (AR)”. Molecular Endocrinology 16 (2): 287–300. doi:10.1210/mend.16.2.0765. PMID 11818501.
^ Bin He, John T. Minges, Lori W. Lee, Elizabeth M. Wilson (22 March 2002). “The FXXLF motif mediates androgen receptor-specific interactions with coregulators”. The Journal of Biological Chemistry 277 (12): 10226–35. doi:10.1074/jbc.M111975200. PMID 11779876.
^ Tianshu Gao, Ken Brantley, Erol Bolu, Michael J. McPhaul (1 October 1999). “RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays”. Molecular Endocrinology 13 (10): 1645–56. doi:10.1210/mend.13.10.0352. PMID 10517667.
^ Bin He and Elizabeth M. Wilson (15 March 2003). “Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs”. Molecular and Cellular Biology 23 (6): 2135–50. doi:10.1128/mcb.23.6.2135-2150.2003. PMC 149467. PMID 12612084.
^ Cynthia A. Heinlein, Huei-Ju Ting, Shuyuan Yeh, Chawnshang, Chang (4 June 1999). “Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma”. The Journal of Biological Chemistry 274 (23): 16147–52. doi:10.1074/jbc.274.23.16147. PMID 10347167.
^ Joseph D. Mancias, Xiaoxu Wang, Steven P. Gygi, J. Wade Harper (1 May 2014). “Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy”. Nature 509 (7498): 105–9. Bibcode: 2014Natur.509..105M. doi:10.1038/nature13148. PMC 4180099. PMID 24695223.
^ William E. Dowdle, Beat Nyfeler, Jane Nagel, Robert A. Elling, Shanming Liu, Ellen Triantafellow, Suchithra Menon, Zuncai Wang, Ayako Honda, Gwynn Pardee, John Cantwell, Catherine Luu, Ivan Cornella-Taracido, Edmund Harrington, Peter Fekkes, Hong Lei, Qing Fang, Mary Ellen Digan, Debra Burdick, Andrew F. Powers, Stephen B. Helliwell, Simon D’Aquin, Julie Bastien, Henry Wang, Dmitri Wiederschain, Jenny Kuerth, Philip Bergman, David Schwalb, Jason Thomas, Savuth Ugwonali, Fred Harbinski, John Tallarico, Christopher J. Wilson, Vic E. Myer, Jeffery A. Porter, Dirksen E. Bussiere, Peter M. Finan, Mark A. Labow, Xiaohong Mao, Lawrence G. Hamann, Brendan D. Manning, Reginald A. Valdez, Thomas Nicholson, Markus Schirle, Mark S. Knapp, Erin P. Keaney & Leon O. Murphy (19 November 2014). “Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo”. Nature Cell Biology 16 (11): 1069–79. doi:10.1038/ncb3053. PMID 253272886
^ Roberto Bellelli, Giorgia Federico, Alessandro Matte', David Colecchia, Achille Iolascon, Mario Chiariello, Massimo Santoro, Lucia De Franceschi, Francesca Carlomagno (26 January 2016). “NCOA4 Deficiency Impairs Systemic Iron Homeostasis”. Cell Reports 14 (3): 411–421. doi:10.1016/j.celrep.2015.12.065. PMID 26776506.

外部リンク

nuclear receptor coactivator 4 - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000266412 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056234 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid8290261-5] M Santoro, N A Dathan, M T Berlingieri, I Bongarzone, C Paulin, M Grieco, M A Pierotti, G Vecchio, A Fusco (February 1994). “Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma”. Oncogene 9 (2): 509–16. PMID 8290261.

[pmid8643607-6] Shuyuan Yeh, and Chawnshang Chang (28 May 1996). “Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells”. Proceedings of the National Academy of Sciences of the United States of America 93 (11): 5517–21. Bibcode: 1996PNAS...93.5517Y. doi:10.1073/pnas.93.11.5517. PMC 39278. PMID 8643607.

[7] “Entrez Gene: NCOA4 Nuclear receptor coactivator 4”. アメリカ国立生物工学情報センター. 2021年8月16日閲覧。

[pmid9892017-8] Philippe Alen, Frank Claessens, Erik Schoenmakers, Johannes V. Swinnen, Guido Verhoeven, Wilfried Rombauts, Ben Peeters (1 January 1999). “Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform”. Molecular Endocrinology 13 (1): 117–28. doi:10.1210/mend.13.1.0214. PMID 9892017.

[pmid9636157-9] Hiroshi Miyamoto, Shuyuan Yeh, George Wilding, and Chawnshang Chang (23 June 1998). “Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells”. Proceedings of the National Academy of Sciences of the United States of America 95 (13): 7379–84. Bibcode: 1998PNAS...95.7379M. doi:10.1073/pnas.95.13.7379. PMC 22623. PMID 9636157.

[pmid11404460-10] Hui-Kuan Lin, Shuyuan Yeh, Hong-Yo Kang, and Chawnshang Chang (19 June 2001). “Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor”. Proceedings of the National Academy of Sciences of the United States of America 98 (13): 7200–5. Bibcode: 2001PNAS...98.7200L. doi:10.1073/pnas.121173298. PMC 34646. PMID 11404460.

[pmid10318905-11] Shuyuan Yeh, Hui-Kuan Lin, Hong-Yo Kang, Tin Htwe Thin, Ming-Fong Lin, and Chawnshang Chang (11 May 1999). “From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells”. Proceedings of the National Academy of Sciences of the United States of America 96 (10): 5458–63. Bibcode: 1999PNAS...96.5458Y. doi:10.1073/pnas.96.10.5458. PMC 21881. PMID 10318905.

[pmid11818501-12] Zhong-xun Zhou, Bin He, Susan H. Hall, Elizabeth M. Wilson, Frank S. French (1 February 2002). “Domain interactions between coregulator ARA(70) and the androgen receptor (AR)”. Molecular Endocrinology 16 (2): 287–300. doi:10.1210/mend.16.2.0765. PMID 11818501.

[pmid11779876-13] Bin He, John T. Minges, Lori W. Lee, Elizabeth M. Wilson (22 March 2002). “The FXXLF motif mediates androgen receptor-specific interactions with coregulators”. The Journal of Biological Chemistry 277 (12): 10226–35. doi:10.1074/jbc.M111975200. PMID 11779876.

[pmid10517667-14] Tianshu Gao, Ken Brantley, Erol Bolu, Michael J. McPhaul (1 October 1999). “RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays”. Molecular Endocrinology 13 (10): 1645–56. doi:10.1210/mend.13.10.0352. PMID 10517667.

[pmid12612084-15] Bin He and Elizabeth M. Wilson (15 March 2003). “Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs”. Molecular and Cellular Biology 23 (6): 2135–50. doi:10.1128/mcb.23.6.2135-2150.2003. PMC 149467. PMID 12612084.

[pmid10347167-16] Cynthia A. Heinlein, Huei-Ju Ting, Shuyuan Yeh, Chawnshang, Chang (4 June 1999). “Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma”. The Journal of Biological Chemistry 274 (23): 16147–52. doi:10.1074/jbc.274.23.16147. PMID 10347167.

[17] Joseph D. Mancias, Xiaoxu Wang, Steven P. Gygi, J. Wade Harper (1 May 2014). “Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy”. Nature 509 (7498): 105–9. Bibcode: 2014Natur.509..105M. doi:10.1038/nature13148. PMC 4180099. PMID 24695223.

[18] William E. Dowdle, Beat Nyfeler, Jane Nagel, Robert A. Elling, Shanming Liu, Ellen Triantafellow, Suchithra Menon, Zuncai Wang, Ayako Honda, Gwynn Pardee, John Cantwell, Catherine Luu, Ivan Cornella-Taracido, Edmund Harrington, Peter Fekkes, Hong Lei, Qing Fang, Mary Ellen Digan, Debra Burdick, Andrew F. Powers, Stephen B. Helliwell, Simon D’Aquin, Julie Bastien, Henry Wang, Dmitri Wiederschain, Jenny Kuerth, Philip Bergman, David Schwalb, Jason Thomas, Savuth Ugwonali, Fred Harbinski, John Tallarico, Christopher J. Wilson, Vic E. Myer, Jeffery A. Porter, Dirksen E. Bussiere, Peter M. Finan, Mark A. Labow, Xiaohong Mao, Lawrence G. Hamann, Brendan D. Manning, Reginald A. Valdez, Thomas Nicholson, Markus Schirle, Mark S. Knapp, Erin P. Keaney & Leon O. Murphy (19 November 2014). “Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo”. Nature Cell Biology 16 (11): 1069–79. doi:10.1038/ncb3053. PMID 253272886

[19] Roberto Bellelli, Giorgia Federico, Alessandro Matte', David Colecchia, Achille Iolascon, Mario Chiariello, Massimo Santoro, Lucia De Franceschi, Francesca Carlomagno (26 January 2016). “NCOA4 Deficiency Impairs Systemic Iron Homeostasis”. Cell Reports 14 (3): 411–421. doi:10.1016/j.celrep.2015.12.065. PMID 26776506.

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