亜硝酸レダクターゼ (NO形成)

亜硝酸レダクターゼ (NO形成)（nitrite reductase (NO-forming)）は、窒素代謝酵素の一つで、次の化学反応を触媒する酸化還元酵素である。

亜硝酸レダクターゼ (NO形成)
識別子
EC番号	1.7.2.1
CAS登録番号	37256-41-0
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBj PDBe PDBsum
遺伝子オントロジー	AmiGO / QuickGO
検索 PMC articles PubMed articles NCBI proteins

一酸化窒素 + H₂O + フェリシトクロムc $\rightleftharpoons$ 亜硝酸 + フェロシトクロムc + 2 H⁺

反応式の通り、この酵素の基質は一酸化窒素とH₂Oとフェリシトクロムc、生成物は亜硝酸とH⁺とフェロシトクロムcである。補因子として、FADと鉄と銅を用いる。

組織名はnitric-oxide:ferricytochrome-c oxidoreductaseで、別名にcd-cytochrome nitrite reductase; [nitrite reductase (cytochrome)] [misleading, see comments.]; cytochrome c-551:O2, NO₂⁺ oxidoreductase; cytochrome cd; cytochrome cd₁; hydroxylamine (acceptor) reductase; methyl viologen-nitrite reductase; nitrite reductase (cytochrome; NO-forming) がある。

参考文献

• Miyata M, Mori T (Tokyo). “Studies on denitrification. X. The "denitrifying enzyme&quot as a nitrite reductase and the electron donating system for denitrification”. J. Biochem.: 463–71. PMID 5354021. 
• CHUNG CW, NAJJAR VA (1956). “Cofactor requirements for enzymatic denitrification. I. Nitrite reductase”. J. Biol. Chem. 218: 617–25. PMID 13295215. 
• Walker GC and Nicholas DJD (1961). “Nitrite reductase from Pseudomonas aeruginosa”. Biochim. Biophys. Acta 49: 350–360. doi:10.1016/0006-3002(61)90134-2. 
• Singh J (1974). “Cytochrome oxidase from Pseudomonas aeruginosa. III. Reduction of hydroxylamine”. Biochim. Biophys. Acta 333: 28–36. 
• Michalski WP and Nicholas DJD (1985). “Molecular characterization of a copper-containing nitrite reductase from Rhodopseudomonas sphaeriodes forma sp. Denitrificans”. Biochim. Biophys. Acta 828: 130–137. 
• J (1991). “The 2.3 angstrom X-ray structure of nitrite reductase from Achromobacter cycloclastes”. Science. 253: 438–42. doi:10.1126/science.1862344. PMID 1862344. 
• SJ, Radford SE, Hajdu J (1995). “Pseudospecific docking surfaces on electron transfer proteins as illustrated by pseudoazurin, cytochrome c550 and cytochrome cd1 nitrite reductase”. Nat. Struct. Biol. 2: 975–82. doi:10.1038/nsb1195-975. PMID 7583671. 
• B, Kroneck PM (1996). “Characterization of the membranous denitrification enzymes nitrite reductase (cytochrome cd1) and copper-containing nitrous oxide reductase from Thiobacillus denitrificans”. Arch. Microbiol. 165: 55–61. doi:10.1007/s002030050296. PMID 8639023. 
• Zumft WG (1997). “Cell biology and molecular basis of denitrification”. Microbiol. Mol. Biol. Rev. 61: 533–616. PMID 9409151. 
• Ferguson SJ (1998). “Nitrogen cycle enzymology”. Curr. Opin. Chem. Biol. 2: 182–93. doi:10.1016/S1367-5931(98)80059-8. PMID 9667932. 
• Vijgenboom E, Busch JE, Canters GW (Pt 9). “In vivo studies disprove an obligatory role of azurin in denitrification in Pseudomonas aeruginosa and show that azu expression is under control of rpoS and ANR”. Microbiology. 143: 2853–63. PMID 9308169.