クアジノン

クアジノン
IUPAC命名法による物質名
	IUPAC名 (3R)-6-chloro-3-methyl-5,10-dihydroimidazo[2,1-b]quinazolin-2(3H)-one;
臨床データ
法的規制	℞ (Prescription only);
データベースID
CAS番号;	70018-51-8
ATCコード	none
PubChem	CID: 6603980
ChemSpider	5036286
UNII	D1Q7F6C2FP
KEGG	D05668
別名	Ro 13-6438
化学的データ
化学式	C11H10ClN3O
分子量	235.67 g/mol
	SMILES Clc1cccc3c1CN2/C(=N\C(=O)[C@H]2C)N3;
	テンプレートを表示

クアジノン(Quazinone)は、1980年代に心血管疾患の治療のために開発、市販された強心剤、血管拡張薬である^[1]^[2]^[3]^[4]^[5]。選択的ホスホジエステラーゼ3阻害薬として作用する^[6]^[7]。現在はもう市販されていない^[1]。

合成

^[8]

出典

^ ^a ^b David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9
^ Eigenmann R, Gerold M, Holck M (1984). “Cardiovascular profile of Ro 13-6438, a novel positive inotropic agent with vasodilating properties”. Journal of Cardiovascular Pharmacology 6 (3): 511-9. doi:10.1097/00005344-198405000-00021. PMID 6202980.
^ Holck M, Thorens S, Muggli R, Eigenmann R (1984). “Studies on the mechanism of positive inotropic activity of Ro 13-6438, a structurally novel cardiotonic agent with vasodilating properties”. Journal of Cardiovascular Pharmacology 6 (3): 520-30. PMID 6202981.
^ Belz GG, Stern HC, Butzer R (1985). “Dose-response following single administrations of a new cardiac performance enhancer RO 13-6438 in normal volunteers”. Journal of Cardiovascular Pharmacology 7 (1): 86-90. doi:10.1097/00005344-198501000-00014. PMID 2580156.
^ Daly PA, Chatterjee K, Viquerat CE, et al. (June 1985). “RO13-6438, a new inotrope-vasodilator: systemic and coronary hemodynamic effects in congestive heart failure”. The American Journal of Cardiology 55 (13 Pt 1): 1539-44. PMID 4003296.
^ Osinski MT, Schror K (August 2000). “Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 inhibitors: role of protein kinase A in vascular smooth muscle cell mitogenesis”. Biochemical Pharmacology 60 (3): 381-7. doi:10.1016/S0006-2952(00)00328-2. PMID 10856433.
^ Denis D, Riendeau D (February 1999). “Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes”. European Journal of Pharmacology 367 (2-3): 343-50. doi:10.1016/S0014-2999(98)00987-X. PMID 10079010.
^ Chodnekar, M. S.; Kaiser, A.; 1981, アメリカ合衆国特許第 4,256,748号

[isbn0-412-46630-9-1] David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9

[pmid6202980-2] Eigenmann R, Gerold M, Holck M (1984). “Cardiovascular profile of Ro 13-6438, a novel positive inotropic agent with vasodilating properties”. Journal of Cardiovascular Pharmacology 6 (3): 511-9. doi:10.1097/00005344-198405000-00021. PMID 6202980.

[pmid6202981-3] Holck M, Thorens S, Muggli R, Eigenmann R (1984). “Studies on the mechanism of positive inotropic activity of Ro 13-6438, a structurally novel cardiotonic agent with vasodilating properties”. Journal of Cardiovascular Pharmacology 6 (3): 520-30. PMID 6202981.

[pmid2580156-4] Belz GG, Stern HC, Butzer R (1985). “Dose-response following single administrations of a new cardiac performance enhancer RO 13-6438 in normal volunteers”. Journal of Cardiovascular Pharmacology 7 (1): 86-90. doi:10.1097/00005344-198501000-00014. PMID 2580156.

[pmid4003296-5] Daly PA, Chatterjee K, Viquerat CE, et al. (June 1985). “RO13-6438, a new inotrope-vasodilator: systemic and coronary hemodynamic effects in congestive heart failure”. The American Journal of Cardiology 55 (13 Pt 1): 1539-44. PMID 4003296.

[pmid10856433-6] Osinski MT, Schror K (August 2000). “Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 inhibitors: role of protein kinase A in vascular smooth muscle cell mitogenesis”. Biochemical Pharmacology 60 (3): 381-7. doi:10.1016/S0006-2952(00)00328-2. PMID 10856433.

[pmid10079010-7] Denis D, Riendeau D (February 1999). “Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes”. European Journal of Pharmacology 367 (2-3): 343-50. doi:10.1016/S0014-2999(98)00987-X. PMID 10079010.

[8] Chodnekar, M. S.; Kaiser, A.; 1981, アメリカ合衆国特許第 4,256,748号

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

IUPAC命名法による物質名

IUPAC名 (3R)-6-chloro-3-methyl-5,10-dihydroimidazo[2,1-b]quinazolin-2(3H)-one
臨床データ
法的規制	℞ (Prescription only)
データベースID
CAS番号	70018-51-8
ATCコード	none
PubChem	CID: 6603980
ChemSpider	5036286
UNII	D1Q7F6C2FP
KEGG	D05668
別名	Ro 13-6438
化学的データ
化学式	C₁₁H₁₀Cl N₃O
分子量	235.67 g/mol
SMILES Clc1cccc3c1CN2/C(=N\C(=O)[C@H]2C)N3
テンプレートを表示

クアジノン

合成

関連項目

出典