キサンチンデヒドロゲナーゼ

キサンチンデヒドロゲナーゼ（xanthine dehydrogenase、XDH）は、ヒトではXDH遺伝子にコードされているタンパク質である。

キサンチンデヒドロゲナーゼ
識別子
EC番号	1.17.1.4
CAS登録番号	9054-84-6
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBj PDBe PDBsum
遺伝子オントロジー	AmiGO / QuickGO
検索 PMC articles PubMed articles NCBI proteins

機能

キサンチンデヒドロゲナーゼは、プリン類の酸化的代謝に関連するモリブデン含有ヒドロキシラーゼに属する。この酵素はホモ二量体である。キサンチンデヒドロゲナーゼは、可逆的スルフヒドリル酸化または非可逆的タンパク質修飾によりキサンチンオキシダーゼに変換される。

キサンチンデヒドロゲナーゼは以下の反応を触媒する：

キサンチン + NAD⁺ + H₂O $\rightleftharpoons$ 尿酸 + NADH + H⁺

この酵素の基質はキサンチン、NAD⁺とH₂Oで、生成物は尿酸、NADHとH⁺である。

この酵素は酸化還元酵素に属し、NAD⁺またはNADP⁺を受容体としてCH基またはCH₂基に特異的に作用する。組織名はxanthine:NAD⁺ oxidoreductaseで、別名にNAD⁺-xanthine dehydrogenase、xanthine-NAD⁺ oxidoreductase、xanthine/NAD⁺ oxidoreductase、xanthine oxidoreductaseがある。プリン代謝酵素の一つである。

参考文献

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