カリカイン

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カリカイン; Caricain
識別子
EC番号	3.4.22.30
CAS登録番号	39307-22-7
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBj PDBe PDBsum
検索
PMC	articles
PubMed	articles
NCBI	proteins
	テンプレートを表示

カリカイン(Caricain、EC 3.4.22.30)は、papaya peptidase A、papaya peptidase II、papaya proteinase、papaya proteinase III、papaya proteinase 3、proteinase omega、papaya proteinase A、chymopapain S、Pp等とも呼ばれる酵素である。以下の化学反応を触媒する^[1]^[2]^[3]^[4]^[5]^[6]。

ペプチド結合に対し広い特異性でタンパク質を加水分解する。パパインやキモパパインに似る。

この酵素は、パパイヤから単離される。

出典

^ Schack, P. (1967). “Fractionation of proteolytic enzymes of dried papaya latex. Isolation and preliminary characterization of a new proteolytic enzyme”. C. R. Trav. Carlesberg 36: 67-83. PMID 6043136.
^ Robinson, G.W. (1975). “Isolation and characterization of papaya peptidase A from commercial chymopapain”. Biochemistry 16: 3695-3700. doi:10.1021/bi00687a028. PMID 240390.
^ Polgár, L. (1984). “Problems of classification of papaya latex proteinases”. Biochem. J. 221: 555-556. PMID 6383350.
^ Brocklehurst, K., Salih, E., McKee, R. and Smith, H. (1985). “Fresh non-fruit latex of Carica papaya contains papain, multiple forms of chymopapain A and papaya proteinase”. Biochem. J. 228: 525-527. PMID 4015629.
^ Zucker, S., Buttle, D.J., Nicklin, M.J.H. and Barrett, A.J. (1985). “Proteolytic activities of papain, chymopapain and papaya proteinase III”. Biochim. Biophys. Acta 828: 196-204. doi:10.1016/0167-4838(85)90057-3. PMID 3919769.
^ Dubois, T., Kleinschmidt, T., Schnek, A.G., Looze, Y. and Braunitzer, G. (1988). “The thiol proteinases from the latex of Carica papaya L. II. The primary structure of proteinase”. Biol. Chem. Hoppe-Seyler 369: 741-754. doi:10.1515/bchm3.1988.369.2.741. PMID 3063283.

外部リンク

Caricain - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）

[1] Schack, P. (1967). “Fractionation of proteolytic enzymes of dried papaya latex. Isolation and preliminary characterization of a new proteolytic enzyme”. C. R. Trav. Carlesberg 36: 67-83. PMID 6043136.

[2] Robinson, G.W. (1975). “Isolation and characterization of papaya peptidase A from commercial chymopapain”. Biochemistry 16: 3695-3700. doi:10.1021/bi00687a028. PMID 240390.

[3] Polgár, L. (1984). “Problems of classification of papaya latex proteinases”. Biochem. J. 221: 555-556. PMID 6383350.

[4] Brocklehurst, K., Salih, E., McKee, R. and Smith, H. (1985). “Fresh non-fruit latex of Carica papaya contains papain, multiple forms of chymopapain A and papaya proteinase”. Biochem. J. 228: 525-527. PMID 4015629.

[5] Zucker, S., Buttle, D.J., Nicklin, M.J.H. and Barrett, A.J. (1985). “Proteolytic activities of papain, chymopapain and papaya proteinase III”. Biochim. Biophys. Acta 828: 196-204. doi:10.1016/0167-4838(85)90057-3. PMID 3919769.

[6] Dubois, T., Kleinschmidt, T., Schnek, A.G., Looze, Y. and Braunitzer, G. (1988). “The thiol proteinases from the latex of Carica papaya L. II. The primary structure of proteinase”. Biol. Chem. Hoppe-Seyler 369: 741-754. doi:10.1515/bchm3.1988.369.2.741. PMID 3063283.

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