アルコールデヒドロゲナーゼ (キノン)
アルコールデヒドロゲナーゼ (キノン)(alcohol dehydrogenase (quinone))は、次の化学反応を触媒する酸化還元酵素である。
| アルコールデヒドロゲナーゼ (キノン) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 識別子 | |||||||||
| EC番号 | 1.1.5.5 | ||||||||
| データベース | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB構造 | RCSB PDB PDBj PDBe PDBsum | ||||||||
| |||||||||
- エタノール + ユビキノン アセトアルデヒド + ユビキノール
この酵素の基質はエタノールとユビキノンで、生成物はアセトアルデヒドとユビキノールである。
この酵素は酸化還元酵素に属し、キノンまたはその類似化合物ピロロキノリンキノンを受容体として供与体であるCH-OH基に特異的に作用する。酢酸菌の細胞表層に局在し、酢酸発酵を行う。組織名はalcohol:quinone oxidoreductaseで、別名にtype III ADH、membrane associated quinohaemoprotein alcohol dehydrogenaseがある。
参考文献
編集- Gomez-Manzo, S., Contreras-Zentella, M., Gonzalez-Valdez, A., Sosa-Torres, M., Arreguin-Espinoza, R. and Escamilla-Marvan, E. (2008). “The PQQ-alcohol dehydrogenase of Gluconacetobacter diazotrophicus.”. Int. J. Food Microbiol. 125: 71-78.. PMID 18321602.
- Shinagawa, E., Toyama, H., Matsushita, K., Tuitemwong, P., Theeragool, G. and Adachi, O. (2006). “A novel type of formaldehyde-oxidizing enzyme from the membrane of Acetobacter sp. SKU 14.”. Biosci. Biotechnol. Biochem. 70: 850-857. PMID 16636451.
- Chinnawirotpisan, P., Theeragool, G., Limtong, S., Toyama, H., Adachi, O.O. and Matsushita, K. (2003). “Quinoprotein alcohol dehydrogenase is involved in catabolic acetate production, while NAD-dependent alcohol dehydrogenase in ethanol assimilation in Acetobacter pasteurianus SKU1108.”. J. Biosci. Bioeng. 96: 564-571. PMID 16233574.
- Frebortova, J., Matsushita, K., Arata, H. and Adachi, O. (1998). “Intramolecular electron transport in quinoprotein alcohol dehydrogenase of Acetobacter methanolicus: a redox-titration stud.”. Biochim. Biophys. Acta 1363: 24-34. PMID 9526036.
- Matsushita, K., Kobayashi, Y., Mizuguchi, M., Toyama, H., Adachi, O., Sakamoto, K. and Miyoshi, H. (2008). “A tightly bound quinone functions in the ubiquinone reaction sites of quinoprotein alcohol dehydrogenase of an acetic acid bacterium, Gluconobacter suboxydans.”. Biosci. Biotechnol. Biochem. 72: 2723-2731.. PMID 18838797.
- Matsushita, K., Yakushi, T., Toyama, H., Shinagawa, E. and Adachi, O. (1996). “Function of multiple heme c moieties in intramolecular electron transport and ubiquinone reduction in the quinohemoprotein alcohol dehydrogenase-cytochrome c complex of Gluconobacter suboxydans.”. J. Biol. Chem. 271: 4850-4857. PMID 8617755.
- Matsushita, K., Takaki, Y., Shinagawa, E., Ameyama, M. and Adachi, O. (1992). “Ethanol oxidase respiratory chain of acetic acid bacteria. Reactivity with ubiquinone of pyrroloquinoline quinone-dependent alcohol dehydrogenases purified from Acetobacter aceti and Gluconobacter suboxydans.”. Biosci. Biotechnol. Biochem. 56: 304-310.
- Matsushita, K., Toyama, H. and Adachi, O. (1994). “Respiratory chains and bioenergetics of acetic acid bacteria.”. Adv. Microb. Physiol. 36: 247-301. PMID 7942316.
- Cozier, G.E., Giles, I.G. and Anthony, C. (1995). “The structure of the quinoprotein alcohol dehydrogenase of Acetobacter aceti modelled on that of methanol dehydrogenase from Methylobacterium extorquens.”. Biochem. J. 308: 375-379. PMID 7772016.